Edna and Harley Whalen, an elderly couple, give shelter to Wade, a suspected murderer on the run. The Whalens do all that they can to protect Wade but evil begets evil in this world, and even more so in Sanctuary.
Barney (Sylvester Stallone) augments his team with new blood for a personal battle: to take down Conrad Stonebanks, the Expendables co-founder and notorious arms trader who is hell bent on wiping out Barney and every single one of his associates.
Mr. Church (Bruce Willis) reunites the Expendables for what should be an easy paycheque, but when one of their men is murdered on the job, their quest for revenge puts them deep in enemy territory and up against an unexpected threat.
Selene, a beautiful vampire warrior, is entrenched in a war between the vampire and werewolf races. Although she is aligned with the vampires, she falls in love with Michael, a werewolf who longs for the war to end.